- Masanori Nakamura, Nagoya Institute of Technology
- Makoto Ohta, Tohoku University
- Marie Oshima, The University of Tokyo
- Juan Cebral, George Mason University
- Anne Robertson, University of Pittsburgh
- Khalid Saqr, Arab Academy for Science and Technology
Cardiovascular and cerebral disease states such as myocardial infarction, cardiomyopathy, atherosclerosis and aneurysm impair our physiological system, possibly resulting in organ failure and, ultimately, death. Simulations can provide clinicians with predictive tools of the efficacy of treatments, contribute to the fundamental understanding of disease progression, and fill current gaps in clinical imaging capabilities. Experiments and measurements are in need to validate and verify the simulations, and to collect parameters to be input for simulations. For clinical applications, simulations must provide not only local mechanics, but also global physiologic and pathologic response. This necessitates a dynamic coupling of models of circulatory physiology at multi-scales in space and time, which give rise to numerical stability and efficiency challenges. Symposium focuses on the basic science and new technologies to overcome these challenges. The presentations will highlight the exciting new developments in approaches to handling the multi-scale coupled systems that arise from cardiovascular and cerebral simulations, including techniques that enable efficient large-scale simulations. Experimental studies are also welcome to demonstrate simulations of the cardiovascular and cerebral system. We hope that this symposium offers an outlook on future directions in the way of understanding the cardiovascular and cerebral system with application to clinical medicine.