0412 modeling and simulation of biological cells

  • Luoding Zhu, Indiana University - Purdue University Indianapolis
  • Jared Barber

Cells are a fundamental building block of all living organisms. The complexity of their structure, function, and native environments, however, can make them difficult to consider in the laboratory. Modeling and simulation often provide a more viable approach for studying the behavior and mechanics of cells. Cellular modeling, however, is not without its own challenges. Cells have membranes, cytoplasms, cytoskeletons, nuclei, and various immersed organelles such as mitochondria. In addition, organisms experience both external and internal macroscopic forces that travel through heterogeneous tissue and affect the resident cells. Crafting models that can be used to understand cellular dynamics frequently requires careful consideration of biomechanics and mechanobiology and often results in challenging multiphysics and multiscale problems. This minisymposium brings together mathematicians, engineers, and scientists engaged in modeling and simulating both generic and specific cells (e.g. osteocytes, red blood cells, and cancer cells). We will exchange and explore ideas, concepts, and results in the area of mechanical modeling of cells including theories, methods, models, and applications regarding parts of cells, single cells, and groups of cells.

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